Urea → HCID 135900180, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (E)-1-(4-hydroxy-3-methylphenyl)-3-(5-methylisoxazol-3-yl)prop-2-en-1-one (200 mg, 0.8 mmol) and urea (56 mg, 4.0 mmol) in 4M HCl/dioxane (5 mL) was heated to 120° C. in a sealed vessel overnight. After cooling, the crude reaction mixture was purified by reverse-phase HPLC to give 9 mg of product.

Provenance & Evidence