Hydrochloric Acid → HCID 178524203, compound

Participants

Reaction Conditions

Reaction Steps

(E)-5-(3-(2-chlorophenyl)acryloyl)thiophene-2-carboxylic acid (1.0 g, 3.4 mmol), urea (1.0 g, 16.6 mmol), and sodium t-butoxide (1.6 g, 16.6 mmol) were suspended in 17 mL of 1,4-dioxane. The reaction mixture was stirred overnight at 80° C. After cooling, the suspension was neutralized by the addition of 1M HCl. The precipitate was filtered, washed with water and air dried to give 740 mg of product. 1H NMR (400 MHz, d6-DMSO): δ 7.89 (s, 1H), 7.63 (m, 2H), 7.56 (t, 1H), 7.50 (t, 1H), 7.24 (d, 1H), 7.07 (s, 1H); MS (EI) for C15H9ClN2O3S: 332 (MH+).

Provenance & Evidence