HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-Methoxypyridine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Hydroxypyridine-2-carbonitrile | HCID 21413773 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Methoxypyridine-2-carbonitrile | HCID 13144279 | 78% |
Reaction Steps
2-Cyano-5-hydroxy pyridine (200 mg, 1.66 mmol), DMF (10 mL) and K2CO3 (253 mg, 1.83 mmol), and MeI (354 mg, 2.49 mmol) were combined at rt and the reaction mixture was stirred for 24 h at rt. The reaction mixture was poured into water and extracted with EtOAc. The organic layer was separated, washed with water, dried and concentrated to give 2-cyano-5-methoxy pyridine (175 mg, 78%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242130B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-ec94e077f7d5473e8837e20a118c1ece |
| Source note | uspto-grants-2012_08 |