Hydrochloric Acid → HCID 11558299, compound

Participants

Reaction Steps

To a solution of 2-(4-acetoxy-phenyl)-1,1-dioxo-1H-1λ6-thiochromen-4-one (260 mg, 0.79 mmol) in MeOH:THF (5 mL:5 mL), K2CO3 (133 mg, 0.95 mmol) was added and stirred for 2 h at rt Then the reaction mixture was neutralized by dilute HCl and extracted by EtOAc, the combined organic layer was washed with water, brine, dried and concentrated to give a crude product, which was purified by column chromatography using 50% EtOAc in hexane, to give 134 mg (59%) of 2-(4-hydroxy-phenyl)-1,1-dioxo-1H-1λ6-thiochromen-4-one. MS (ES) m/z: 286.05 (M), 285.01 (M−1); Mp. 222-224° C.

Provenance & Evidence