Cyclopentylamine → HCID 59253059, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-acetyl-3-((S)-1-phenyl-propylamino)-isochromen-1-one (60 mg) and cyclopentylamine (0.06 mL) in acetonitrile (0.2 mL) was heated under microwave irradiation at 170° C. for 15 min. The reaction mixture was partitioned between 2M HCl (3 mL) and ethyl acetate (3 mL). The organic phase was absorbed on SiO2 and flash chromatographed (20 g SiO2 column, gradient heptane-ethyl acetate, the product came out with 40% ethyl acetate) to give 18 mg of the title compound as a colourless solid. LC-MS (m/z) 389.5 (MH+); tR=1.52.

Provenance & Evidence