Trifluoroacetic acid → 3-[5-Amino-4-benzoyl-3-(piperidin-4-yloxy)-pyrazol-1-yl]-n-cyclopropyl-4-methyl-benzamide, trifluoroacetate salt

Participants

Reaction Steps

To a solution of 4-[5-amino-4-benzoyl-1-(5-cyclopropylcarbamoyl-2-methyl-phenyl)-1H-pyrazol-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester 8 (5.0 mg, 0.0089 mmol) in dichloromethane (2.0 ml) was added trifluoroacetic acid (0.5 ml). The mixture was stirred at room temperature for 3 h. Volatiles were removed in vacuo and the residue was washed with ether and a small amount of EtOAc to give the desired 3-[5-amino-4-benzoyl-3-(piperidin-4-yloxy)-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide, trifluoroacetate salt 9 as a white solid (3.0 mg, 59%). HPLC (4 minute 10-90 gradient) tR 1.75 min; MS m/z 460.1 [M+H]+; 1H NMR (DMSO-d6, 300 MHz) δ 8.50 (d, J=4.0, 1 H), 8.33 (bs, 2 H), 7.90 (d, J=8.0, 1 H), 7.83 (s, 1 H), 7.62 (d, J=7.0, 2 H), 7.44-7.52 (m, 4 H), 7.03 (bs, 2 H), 4.82 (m, 1 H), 2.97 (m, 2 H), 2.85 (m, 1 H), 2.73 (m, 2 H), 2.27 (s, 3 H), 1.91 (m, 2 H), 1.73 (m, 2 H), 0.71 (m, 2 H), 0.57 (m, 2 H) ppm.

Provenance & Evidence