Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (R)-2-Cyclopentyl-2-hydroxy-2-phenyl-1-piperazin-1-ylethanone | HCID 57613502 | — |
| Product | Hydrochloric Acid | HCID 313 | 93.3% |
| Product | 3-Phenylpropionimidic acid ethyl ester | HCID 10352235 | — |
Reaction Steps
HCl (26 mg, 150 mol) and (R)-2-cyclopentyl-2-hydroxy-2-phenyl-1-piperazin-1-ylethanone (43 mg, 150 mol) were combined in DMF (1.0 mL). DIPEA (52 μL, 0.3 mmol) was added, and the mixture was heated at 40° C. for 14 hours. The mixture was then condensed in vacuo and purified by reverse phase HPLC to obtain the title compound as an HCl salt (23 mg, 0.1 mmol, 93.3% purity). MS m/z: [M+H]+ calcd for C26H33N3O2, 420.26; found 420.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08242138B2 |
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| Source dataset | uspto-grants-2012_08 |
|---|
| ORD ID | ord-7d569b02662f474896c68b834fbd52bf |
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| Source note | uspto-grants-2012_08 |
|---|
