反应详情

A 300 mL Fisher Porter vessel equipped with magnetic stirring bar was charged with 7.2 g benzyl 3-(4-tert-butoxycarbonylpiperizin-1-ylsulfonyl)-2(R)-methylpropionate, 600 mg 10% Pd—C, and 100 mL MeOH. The reaction vessel was charged with 50 psi H2 and stirred for 2 hours at room temperature. The reaction mixture was filtered thru Celite and concentrated in vacuo to yield 5.25 g (93%) white solid. The free acid was used without further purification.

1. customA 300 mL Fisher Porter vessel equipped with magnetic stirring bar
2. additionThe reaction vessel was charged with 50 psi H2
3. filtrationThe reaction mixture was filtered thru Celite
4. concentrationconcentrated in vacuo