1H-1,2,4-Triazole → HCID 44555546, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(7-bromo-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-(pyridin-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethane-1,2-dione (80 mg, 0.163 mmol), 1H-1,2,4-triazole (45.0 mg, 0.651 mmol) and copper (20.69 mg, 0.326 mmol) in pyridine (1 mL) was heated at 145° C. for 10 hours, LCMS indicated the formation of desired product. The reaction mixture was filtered and the clear solution purified by prep. HPLC to give 1-(4-methoxy-7-(1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-(pyridin-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethane-1,2-dione as pale yellow solid (28 mg, 35%). LCMS: m/e 480.11 (M+H)+, 1.52 min (method 9). 1H NMR (500 MHz, MeOD) δ ppm 2.81-3.10 (m, 2H) 3.70-4.04 (m, 5H) 4.76-5.10 (m, 2H) 7.37-7.72 (m, 3H) 7.80-7.93 (m, 1H) 8.00-8.22 (m, 2H) 8.30-8.42 (m, 2H) 8.55-8.75 (m, 1H) 8.83-8.99 (m, 1H) 9.39 (s, 1H).

Provenance & Evidence