1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(4-(pyridin-2-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethane-1,2-dione → 1-(4-methoxy-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(4-(pyridin-2-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethane-1,2-dione

Participants

Reaction Steps

The procedure described in Part E of preparation of compound 18 above was employed for the coupling of 4-(pyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride with 2-(4-methoxy-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid to afford 1-(4-methoxy-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(4-(pyridin-2-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethane-1,2-dione; HRMS: 486.1677 (M+H)+ [calc'd: 486.1684]; 1HNMR (500 MHz, DMSO-d6) δ 12.82 (br s, 1H), 9.18 (s, 2/3H), 9.09 (s, 1/3H), 8.95 (s, 1H), 8.78 (m, 1/3H), 8.68 (m, 2/3H), 8.34 (s, 2/3H), 8.26 (s, 1/3H), 8.12-8.01 (m, 3H), 7.97 (s, 1H), 7.58 (m, 1/3H), 7.53 (m, 2/3H), 4.93 (s, 4/3H), 4.73 (s, 2/3H), 3.96 (s, 1H), 3.93 (m, 2/3H), 3.90 (s, 2H), 3.70 (m, 4/3H), 3.32 (m, 2/3), 3.18 (m, 4/3H).

Provenance & Evidence