Ethanol → HCID 46893145, compound

HRID 885147Notes

Reaction equation

HRID 885147 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3](O)=O.F[C:9](F)([N:21]1[CH:25]=[C:24]([C:26]2[CH:31]=[CH:30][C:29]([N:32]3[CH:36]=[C:35]([CH3:37])[N:34]=[CH:33]3)=[C:28]([O:38][CH3:39])[CH:27]=2)[N:23]=[N:22]1)[C:10]([NH:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)=[O:11].[CH2:41](O)C>>[F:20][C:17]1[C:16]2[CH2:15][CH2:41][C@H:9]([N:21]3[CH:25]=[C:24]([C:26]4[CH:31]=[CH:30][C:29]([N:32]5[CH:36]=[C:35]([CH3:37])[N:34]=[CH:33]5)=[C:28]([O:38][CH3:39])[CH:27]=4)[N:23]=[N:22]3)[C:10](=[O:11])[N:12]([CH2:3][C:2]([F:7])([F:6])[F:1])[C:13]=2[CH:14]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 86644982HCID 86644982, compound

Product 1

HCID 46893145HCID 46893145, compound

Procedure

Resolution (of the free base):75% ethanol/25% heptane Column: Chiralcel OJ-H; 254 nm detection; enantiomer 1 (465 mg), enantiomer 2 (489 mg).

Sources & evidence

ORD record
ord-2b577b03434646ea88c580b7d45689c9
Source dataset
uspto-grants-2012_08
Patent number
US08242150B2

Reaction notes

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