HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanogen Bromide → (4S)-4-(4,4,4-trifluoro-3-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | (S)-2-Amino-6,6,6-trifluoro-5-phenyl-hexan-1-ol | HCID 67177841 | — |
| Product | (4S)-4-(4,4,4-trifluoro-3-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine | HCID 45101018 | — |
Reaction Steps
In analogy to example 1d (S)-2-amino-6,6,6-trifluoro-5-phenyl-hexan-1-ol was reacted with cyanogen bromide to give (4S)-4-(4,4,4-trifluoro-3-phenyl-butyl)-4,5-dihydro-oxazol-2-ylamine. White solid. MS (ISP): 273.1 ([M+H]+))
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242153B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-9e35ebdf14524154ae78634db8cf1944 |
| Source note | uspto-grants-2012_08 |