Cyanogen Bromide → HCID 45102519, compound

HRID 885188Notes

Reaction equation

HRID 885188 reaction equation
[NH2:1][C@@H:2]([CH2:5][C@@H:6]([O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)[CH3:7])[CH2:3][OH:4].[N:16]#[C:17]Br>>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([O:8][C@@H:6]([CH3:7])[CH2:5][C@H:2]2[CH2:3][O:4][C:17]([NH2:16])=[N:1]2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 59173172HCID 59173172, compound

Product 1

HCID 45102519HCID 45102519, compound

Procedure

In analogy to example 1d (2S,4S)-2-amino-4-(4-chloro-phenoxy)-pentan-1-ol was reacted with cyanogen bromide to give (S)-4-[(S)-2-(4-chloro-phenoxy)-propyl]-4,5-dihydro-oxazol-2-ylamine. Light yellow solid. MS (ISP): 257.2 ([{37Cl}M+H]+), 255.2 ([{35Cl}M+M]+).

Sources & evidence

ORD record
ord-e0dc7d01df9c4da7b18b78282692be30
Source dataset
uspto-grants-2012_08
Patent number
US08242153B2

Reaction notes

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