HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (S)-2-amino-5-(4-chloro-phenyl)-5-methoxy-pentan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-4-[3-(4-chloro-phenyl)-3-methoxy-propyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester | HCID 59173153 | — |
| Product | (S)-2-amino-5-(4-chloro-phenyl)-5-methoxy-pentan-1-ol | HCID 59173183 | — |
Reaction Steps
In analogy to example 45c (S)-4-[3-(4-chloro-phenyl)-3-methoxy-propyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester was reacted with trifluoroacetic acid to give (S)-2-amino-5-(4-chloro-phenyl)-5-methoxy-pentan-1-ol. Yellow oil. MS (ISP): 246.1 ([{37Cl}M+H]+), 244.1 ([{35Cl}M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242153B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-252e0ebfe3674bdb90566c083bc7b8e1 |
| Source note | uspto-grants-2012_08 |