Cyanogen Bromide → (S)-4-[3-(4-chloro-phenyl)-3-methoxy-propyl]-4,5-dihydro-oxazol-2-ylamine

Participants

Role	Name	HCID	Charge
Reactant	Cyanogen Bromide	HCID 10476	—
Reactant	(S)-2-amino-5-(4-chloro-phenyl)-5-methoxy-pentan-1-ol	HCID 59173183	—
Product	(S)-4-[3-(4-chloro-phenyl)-3-methoxy-propyl]-4,5-dihydro-oxazol-2-ylamine	HCID 59173114	—

Reaction Steps

In analogy to example 1d (S)-2-amino-5-(4-chloro-phenyl)-5-methoxy-pentan-1-ol was reacted with cyanogen bromide to give (S)-4-[3-(4-chloro-phenyl)-3-methoxy-propyl]-4,5-dihydro-oxazol-2-ylamine (mixture of epimers). White solid. MS (ISP): 271.2 ([{37Cl}M+H]+), 269.2 ([{35Cl}M+H]+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08242153B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-2a9cf62983704a82bbedb70053a2b3ae
Source note	uspto-grants-2012_08