Cyanogen Bromide → HCID 45101817, compound

HRID 885212Notes

Reaction equation

HRID 885212 reaction equation
[NH2:1][C@@H:2]([CH2:5][CH2:6][S:7][C:8]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=1)[CH2:3][OH:4].[N:15]#[C:16]Br>>[F:14][C:11]1[CH:10]=[CH:9][C:8]([S:7][CH2:6][CH2:5][C@H:2]2[CH2:3][O:4][C:16]([NH2:15])=[N:1]2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 67178957HCID 67178957, compound

Product 1

HCID 45101817HCID 45101817, compound

Procedure

In analogy to example 1d (S)-2-amino-4-(4-fluoro-phenylsulfanyl)-butan-1-ol was reacted with cyanogen bromide to give (S)-4-[2-(4-fluoro-phenylsulfanyl)-ethyl]-4,5-dihydro-oxazol-2-ylamine. Colourless oil. MS (ISP): 241.2 ([M+H]+).

Sources & evidence

ORD record
ord-47f2f53349f54f19b03fd8c48e5ada2b
Source dataset
uspto-grants-2012_08
Patent number
US08242153B2

Reaction notes

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