Cyanogen Bromide → HCID 59173090, compound

HRID 885214Notes

Reaction equation

HRID 885214 reaction equation
[NH2:1][C@@H:2]([CH2:5][CH2:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)(=[O:9])=[O:8])[CH2:3][OH:4].[N:17]#[C:18]Br>>[F:16][C:13]1[CH:12]=[CH:11][C:10]([S:7]([CH2:6][CH2:5][C@H:2]2[CH2:3][O:4][C:18]([NH2:17])=[N:1]2)(=[O:9])=[O:8])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 67176856HCID 67176856, compound

Product 1

HCID 59173090HCID 59173090, compound

Procedure

In analogy to example 1d (S)-2-amino-4-(4-fluoro-phenylsulfonyl)-butan-1-ol was reacted with cyanogen bromide to give (S)-4-[2-(4-fluoro-phenylsulfonyl)-ethyl]-4,5-dihydro-oxazol-2-ylamine. Colourless oil. MS (ISP): 273.1 ([M+H]+).

Sources & evidence

ORD record
ord-9b915db455084986be4d147910714c76
Source dataset
uspto-grants-2012_08
Patent number
US08242153B2

Reaction notes

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