Cyanogen Bromide → HCID 45101819, compound

HRID 885218Notes

Reaction equation

HRID 885218 reaction equation
[NH2:1][C@@H:2]([CH2:5][O:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)([CH3:9])[CH3:8])[CH2:3][OH:4].[N:17]#[C:18]Br>>[F:16][C:13]1[CH:12]=[CH:11][C:10]([C:7]([CH3:9])([O:6][CH2:5][C@H:2]2[CH2:3][O:4][C:18]([NH2:17])=[N:1]2)[CH3:8])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 67180539HCID 67180539, compound

Product 1

HCID 45101819HCID 45101819, compound

Procedure

In analogy to example 1d, (R)-2-amino-3-[1-(4-fluoro-phenyl)-1-methyl-ethoxy]-propan-1-ol was reacted with cyanogen bromide to give (S)-4-[1-(4-fluoro-phenyl)-1-methyl-ethoxymethyl]-4,5-dihydro-oxazol-2-ylamine. Colourless oil. MS (ISP): 253.3 ([M+H]+).

Sources & evidence

ORD record
ord-a154a0c4f84d47048743e4848c5e1587
Source dataset
uspto-grants-2012_08
Patent number
US08242153B2

Reaction notes

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