Potassium Carbonate → [3-(2-Formyl-phenoxy)-phenyl]-acetic acid ethyl ester

Participants

Reaction Conditions

Reaction Steps

(3-Hydroxy-phenyl)-acetic acid ethyl ester (1.0 g, 5.2 mmol), 2-fluorobenzaldehyde (0.66 g, 5.2 mmol), and potassium carbonate (1.44 g, 10.4 mmol) were combined in 1,4-dioxane (30 mL) and heated to 120° C. for 3 days. After work-up, the crude material was purified by silica gel chromatography (0-20% EtOAc in hexanes) to give the desired product (1 g).

Provenance & Evidence