HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → [3-(2-Bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | [3-(2-Hydroxymethyl-phenoxy)-phenyl]-acetic acid ethyl ester | HCID 58237647 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [3-(2-Bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester | HCID 58237656 | 54.7% |
Reaction Steps
To [3-(2-hydroxymethyl-phenoxy)-phenyl]-acetic acid ethyl ester (0.90 g, 3.14 mmol) in 1,4-dioxane was added phosphorus tribromide (0.38 mL, 4.1 mmol), and the reaction was stirred for 1 hour at mom temperature. After work-up, 0.6 g of the desired product was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242145B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-0c4f99da6a8a4b69aa35cfcd051597b0 |
| Source note | uspto-grants-2012_08 |