HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → [3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | [3-(4-Bromo-2-hydroxymethyl-phenoxy)-phenyl]-acetic acid ethyl ester | HCID 58237503 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester | HCID 58237602 | 75.3% |
Reaction Steps
To [3-(4-bromo-2-hydroxymethyl-phenoxy)-phenyl]-acetic acid ethyl ester (0.7 g, 1.86 mmol) in 1,4-dioxane (10 mL) was added phosphorus tribromide (0.19 mL, 2.04 mmol), and the reaction was stirred for 1 hour at room temperature. After work-up, 0.6 g of the desired product was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242145B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-21b7adda40d34c2cbf5f59cf3b4a9824 |
| Source note | uspto-grants-2012_08 |