HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → (3-{2-[(2-Hydroxy-ethylamino)-methyl]-4-trifluoromethyl-phenoxy}-phenyl)-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | [3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid | HCID 58237662 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (3-{2-[(2-Hydroxy-ethylamino)-methyl]-4-trifluoromethyl-phenoxy}-phenyl)-acetic acid | HCID 58237504 | 109.8% |
Reaction Steps
[3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid (0.12 g, 0.37 mmol), ethanolamine (0.02 mL, 0.37 mmol), and sodium triacetoxyborohydride (0.12 g, 0.56 mmol) were combined in CH2Cl2 (10 mL) and stilled for 2 hours. After work-up, 0.15 g of the desired product was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242145B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-0b3fae92d8a2430196c49dfafbd54957 |
| Source note | uspto-grants-2012_08 |