HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885264Generated: October 31, 2026
Water → 2-(2-Bromo-5-methoxyphenyl)acetonitrile
https://huagongshe.com/reaction/885264
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 2-Bromo-5-methoxybenzyl bromide | HCID 3525951 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-(2-Bromo-5-methoxyphenyl)acetonitrile | HCID 639666 | — |
Reaction Steps
2-Bromo-5-methoxybenzyl bromide (2 g, 7.1 mmol) and sodium cyanide (0.526 g, 10.7 mmol) were combined in DMSO (20 mL) and heated to 90° C. for 3 hours. Once no starting material was seen by analytical tlc, the mixture was worked-up with H2O and EtOAc to give the desired product as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08242145B2 |
|---|
| Source dataset | uspto-grants-2012_08 |
|---|
| ORD ID | ord-d0793a1c9aaf43ea94f1b6e925b01d42 |
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| Source note | uspto-grants-2012_08 |
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