HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885267Generated: October 30, 2026
Hydrochloric Acid → (2-Bromo-5-hydroxy-phenyl)-acetic acid methyl ester
https://huagongshe.com/reaction/885267
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-(2-Bromo-5-hydroxyphenyl)acetic acid | HCID 57257821 | — |
| Product | (2-Bromo-5-hydroxy-phenyl)-acetic acid methyl ester | HCID 58237580 | — |
Reaction Steps
To (2-bromo-5-hydroxy-phenyl)-acetic acid (1.5 g, 6.5 mmol) in MeOH (15 mL) was added HCl (4N in 1,4-dioxane; 3 mL), and the solution was heated to 70° C. for 8 hours. The mixture was concentrated to give the desired product as a white solid (1.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08242145B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-ae8102e6250c4aa39cf8a1804d19e967 |
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| Source note | uspto-grants-2012_08 |
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