2-Fluoro-5-(trifluoromethyl)benzaldehyde → [2-Bromo-5-(2-formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

HRID 885268Notes

Reaction equation

HRID 885268 reaction equation
[CH3:1][O:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:6]=1[Br:12].F[C:15]1[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][C:16]=1[CH:17]=[O:18]>>[CH3:1][O:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[C:9]([O:11][C:15]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][C:16]=2[CH:17]=[O:18])[CH:8]=[CH:7][C:6]=1[Br:12]

Participants

3

Reactant 2

HCID 27349042-Fluoro-5-(trifluoromethyl)benzaldehydeHCID 58237580(2-Bromo-5-hydroxy-phenyl)-acetic acid methyl ester

Product 1

HCID 58237648[2-Bromo-5-(2-formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 9, Step 2, using the following starting materials: (2-bromo-5-hydroxy-phenyl)-acetic acid methyl ester and 2-fluoro-5-(trifluoromethyl)benzaldehyde.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c8491212112542d7b9bd1262307db23e
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

Loading…