1-Bromo-3,5-difluorobenzene → HCID 67105363, compound

HRID 885277Notes

Reaction equation

HRID 885277 reaction equation
[CH2:1]([O:8][C:9](=[O:19])[NH:10][C@H:11]([C:13](=[O:18])N(OC)C)[CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[CH:22]=1>>[CH2:1]([O:8][C:9](=[O:19])[NH:10][C@@H:11]([CH3:12])[C:13]([C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[C:23]([F:28])[CH:22]=1)=[O:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1363131-Bromo-3,5-difluorobenzeneHCID 10515879(S)-Benzyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate

Product 1

HCID 67105363HCID 67105363, compound

Procedure

Prepared according to the procedure described in Example 16, Step 2, using the following starting materials: [(S)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid benzyl ester and 1-bromo-3,5-difluorobenzene.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0cd9f58b0457487fbf28ccbacdf47ecb
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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