(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one → HCID 58237514, compound

HRID 885280Notes

Reaction equation

HRID 885280 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19]Br)[CH:6]=1.[F:22][C:23]([F:42])([F:41])[C:24]1[CH:25]=[C:26]([C@H:34]2[O:38][C:37](=[O:39])[NH:36][C@H:35]2[CH3:40])[CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1>>[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19][N:36]2[C@@H:35]([CH3:40])[C@@H:34]([C:26]3[CH:27]=[C:28]([C:30]([F:32])([F:33])[F:31])[CH:29]=[C:24]([C:23]([F:22])([F:41])[F:42])[CH:25]=3)[O:38][C:37]2=[O:39])[CH:6]=1

Participants

3

Reactant 2

HCID 23583229(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-oneHCID 58237479[3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]acetic acid methyl ester

Product 1

HCID 58237514HCID 58237514, compound

Procedure

Prepared according to the procedure described in Example 6, Step 5, using the following starting materials: [3-(4-bromo-2-bromomethyl-phenoxy)-phenyl]-acetic acid methyl ester and (4S,5R)-5-(3,5-bis-trifluoromethyl-phenyl)-4-methyl-oxazolidin-2-one.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0580ecb752de487bad88bd72d3eccfd0
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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