1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → HCID 44188074, compound

HRID 885283Notes

Reaction equation

HRID 885283 reaction equation
Br[C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH2:13][C:14]([OH:16])=[O:15])[CH:10]=[CH:11][CH:12]=2)=[C:4]([CH2:19][N:20]2[C@@H:24]([CH3:25])[C@@H:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[O:22][C:21]2=[O:32])[CH:3]=1.[CH3:33][N:34]1[CH:38]=[C:37](B2OC(C)(C)C(C)(C)O2)[CH:36]=[N:35]1>>[CH3:25][C@H:24]1[C@@H:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[O:22][C:21](=[O:32])[N:20]1[CH2:19][C:4]1[CH:3]=[C:2]([C:37]2[CH:36]=[N:35][N:34]([CH3:33])[CH:38]=2)[CH:18]=[CH:17][C:5]=1[O:6][C:7]1[CH:8]=[C:9]([CH2:13][C:14]([OH:16])=[O:15])[CH:10]=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 27739871-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 44187897HCID 44187897, compound

Product 1

HCID 44188074HCID 44188074, compound

Procedure

Prepared according to the procedure described in Example 19, Step 3, using the following starting materials: {3-[4-bromo-2-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid and 1-methylpyrazole-4-boronic acid pinacol ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-faed0c6aaca7493ba398d568e16d76f2
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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