Benzyl Alcohol → (5-Benzyloxy-2-chloro-phenyl)-acetic acid

Participants

Reaction Steps

To benzyl alcohol (1.1 g, 10 mmol) in NMP (20 mL) was added sodium hydride (60% in mineral oil; 0.44 g, 11 mmol), and the mixture was stirred for 30 minutes at room temperature. The mixture was then added to a vial containing 2-chloro-5-fluorophenylacetic acid (1 g, 4.5 mmol), and the reaction was stirred at 120° C. for 3 hours. Acidic work-up gave the desired product (1.8 g).

Provenance & Evidence