5-Chloro-2-fluorobenzaldehyde → [3-(4-Chloro-2-formyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester

HRID 885308Notes

Reaction equation

HRID 885308 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([OH:14])[CH:7]=1)[CH3:2].[Cl:16][C:17]1[CH:18]=[CH:19][C:20](F)=[C:21]([CH:24]=1)[CH:22]=[O:23]>>[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:20]2[CH:19]=[CH:18][C:17]([Cl:16])=[CH:24][C:21]=2[CH:22]=[O:23])[CH:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27735865-Chloro-2-fluorobenzaldehydeHCID 5324706Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

Product 1

HCID 58237578[3-(4-Chloro-2-formyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 24, Step 4, using the following starting materials: (3-hydroxy-4-methoxy-phenyl)-acetic acid ethyl ester and 5-chloro-2-fluorobenzaldehyde.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e55a017a55674ba8b2dafbd351df5e05
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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