2-Fluoro-5-(trifluoromethyl)benzaldehyde → [3-(2-Formyl-4-trifluoromethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester

HRID 885311Notes

Reaction equation

HRID 885311 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([OH:14])[CH:7]=1)[CH3:2].F[C:17]1[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][C:18]=1[CH:19]=[O:20]>>[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:17]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][C:18]=2[CH:19]=[O:20])[CH:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27349042-Fluoro-5-(trifluoromethyl)benzaldehydeHCID 5324706Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

Product 1

HCID 58237587[3-(2-Formyl-4-trifluoromethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 10, Step 4, using the following starting materials: (3-hydroxy-4-methoxy-phenyl)-acetic acid ethyl ester and 2-fluoro-5-(trifluoromethyl)benzaldehyde.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7620f8e38c1446509aed9864167546ce
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

Loading…