HuagongsheHuagongshe Chemistry Print Report · For research reference only
phenylalaninol, (S)- → HCID 58237470, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | phenylalaninol, (S)- | HCID 447213 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | [3-(4-Bromo-2-formyl-phenoxy)-phenyl]-acetic acid methyl ester | HCID 58237467 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58237470 | HCID 58237470 | — |
Reaction Steps
[3-(4-Bromo-2-formyl-phenoxy)-phenyl]-acetic acid methyl ester (0.166 g, 0.49 mmol), (S)-(−)-2-amino-3-phenyl-1-propanol (0.091 g, 0.6 mmol), sodium cyanoborohydride (0.062 g, 1.0 mmol), and acetic acid (1 drop) were combined in CH2Cl2 (10 mL) and stirred overnight at room temperature. After aqueous work-up, the crude material was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242145B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-696c31059ef74e7c9441046225346d07 |
| Source note | uspto-grants-2012_08 |