(4R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one → (3-{2-[(4R,5S)-5-(3,5-Bis-trifluoromethyl-phenyl)-4-methyl-2-oxo-oxazolidin-3-ylmethyl]-4-bromo-phenoxy}-4-methoxy-phenyl)-acetic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	(4R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one	HCID 53364081	—
Reactant	[3-(4-Bromo-2-bromomethyl-phenoxy)-4-methoxy-phenyl]-acetic acid methyl ester	HCID 58237646	—
Product	(3-{2-[(4R,5S)-5-(3,5-Bis-trifluoromethyl-phenyl)-4-methyl-2-oxo-oxazolidin-3-ylmethyl]-4-bromo-phenoxy}-4-methoxy-phenyl)-acetic acid methyl ester	HCID 58237490	—

Reaction Steps

Prepared according to the procedure described in Example 6, Step 5, using the following starting materials: [3-(4-bromo-2-bromomethyl-phenoxy)-4-methoxy-phenyl]-acetic acid methyl ester and (4R,5S)-5-(3,5-bis-trifluoromethyl-phenyl)-4-methyl-oxazolidin-2-one.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08242145B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-99bf2547bc9d459ba8bc09486d35cc13
Source note	uspto-grants-2012_08