5-Bromo-2,4-dimethyl-1,3-thiazole → HCID 58237571, compound

HRID 885358Notes

Reaction equation

HRID 885358 reaction equation
[CH2:1]([O:3][C:4](=[O:42])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16](B3OC(C)(C)C(C)(C)O3)=[CH:15][C:14]=2[CH2:28][N:29]2[C@@H:33]([CH3:34])[C@@H:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[O:31][C:30]2=[O:41])[CH:7]=1)[CH3:2].Br[C:44]1[S:48][C:47]([CH3:49])=[N:46][C:45]=1[CH3:50]>>[CH2:1]([O:3][C:4](=[O:42])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([C:44]3[S:48][C:47]([CH3:49])=[N:46][C:45]=3[CH3:50])=[CH:15][C:14]=2[CH2:28][N:29]2[C@@H:33]([CH3:34])[C@@H:32]([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[O:31][C:30]2=[O:41])[CH:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2986285-Bromo-2,4-dimethyl-1,3-thiazoleHCID 58237457{3-[2-((4S,5R)-4-Methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-phenyl}-acetic acid ethyl ester

Product 1

HCID 58237571HCID 58237571, compound

Procedure

Prepared according to the procedure described in Example 19, Step 3, using the following starting materials: {3-[2-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-phenyl}-acetic acid ethyl ester and 5-bromo-2,4-dimethyl-1,3-thiazole.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d0f3d02861234134b012f17b31e48430
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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