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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885364Generated: October 31, 2026

Hydrochloric Acid → HCID 58237633, compound

https://huagongshe.com/reaction/885364

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantMethanolHCID 887—
ReactantHCID 58237533HCID 58237533—
ProductHCID 58237633HCID 58237633—

Reaction Conditions

Temperature80 °C

Reaction Steps

To {4-hydroxy-3-[2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4-trifluoromethyl-phenoxy]-phenyl}-acetic acid (1.5 g, 3.74 mmol) in MeOH was added hydrochloric acid (4N in 1,4-dioxane), and the reaction was stirred at 80° C. for 2 hours. The mixture was concentrated to dryness, and the residue was worked-up with EtOAc and saturated aqueous NaHCO3 to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08242145B2
Source datasetuspto-grants-2012_08
ORD IDord-3587263b857b4d798ae5f7277cb71fab
Source noteuspto-grants-2012_08