1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → HCID 58237651, compound

HRID 885365Notes

Reaction equation

HRID 885365 reaction equation
[CH3:1][O:2][C:3](=[O:44])[CH2:4][C:5]1[CH:10]=[CH:9][C:8](OS(C(F)(F)F)(=O)=O)=[C:7]([O:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][C:21]=2[CH2:30][N:31]2[C@H:35]([CH3:36])[C@H:34]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[O:33][C:32]2=[O:43])[CH:6]=1.[CH3:45][N:46]1[CH:50]=[C:49](B2OC(C)(C)C(C)(C)O2)[CH:48]=[N:47]1>>[CH3:1][O:2][C:3](=[O:44])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:49]2[CH:48]=[N:47][N:46]([CH3:45])[CH:50]=2)=[C:7]([O:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:29])[F:28])=[CH:22][C:21]=2[CH2:30][N:31]2[C@H:35]([CH3:36])[C@H:34]([C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[O:33][C:32]2=[O:43])[CH:6]=1

Participants

3

Reactant 2

HCID 27739871-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 58237573HCID 58237573, compound

Product 1

HCID 58237651HCID 58237651, compound

Procedure

Prepared according to the procedure described in Example 19, Step 3, using the following starting materials: {3-[2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4-trifluoromethyl-phenoxy]-4-trifluoromethanesulfonyloxy-phenyl}-acetic acid methyl ester and 1-methylpyrazole-4-boronic acid pinacol ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5422d1e8b6f548af937ff23ae81d3d9b
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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