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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885369Generated: October 31, 2026

Iodoethane → HCID 58237654, compound

https://huagongshe.com/reaction/885369

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodoethaneHCID 6340—
ReactantCesium carbonateHCID 10796—
ReactantHCID 58237618HCID 58237618—
SolventAcetonitrileHCID 6342—
ProductHCID 58237654HCID 58237654—

Reaction Steps

To {4-hydroxy-3-[2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4-trifluoromethyl-phenoxy]-phenyl}-acetic acid ethyl ester (0.060 g, 0.12 mmol) in MeCN (2 mL) was added cesium carbonate (0.086 g, 0.26 mmol) and iodoethane (0.02 mL, 0.26 mmol), and the reaction was stirred at room temperature overnight. After work-up with EtOAc and 10% aqueous HCl, the crude material was purified by silica gel chromatography to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08242145B2
Source datasetuspto-grants-2012_08
ORD IDord-754cf1f6938540f089427c85b1be891b
Source noteuspto-grants-2012_08