Morpholine → {4-Methoxy-3-[4-morpholin-4-yl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester

Participants

Reaction Conditions

Reaction Steps

{3-[4-Bromo-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-4-methoxy-phenyl}-acetic acid ethyl ester (0.2 g, 0.43 mmol), morpholine (0.05 mL, 0.52 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.01 g, 0.01 mmol), BINAP (0.026 g, 0.04 mmol), and sodium tert-butoxide (0.09 g, 0.86 mmol) were combined in toluene (10 mL) and stirred at 100° C. for 2 hours. The mixture was worked-up to give the title compound.

Provenance & Evidence