HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885378Generated: October 30, 2026
Methanol → {4-Methoxy-3-[4-morpholin-4-yl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid
https://huagongshe.com/reaction/885378
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | {4-Methoxy-3-[4-morpholin-4-yl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester | HCID 58237477 | — |
| Solvent | Water | HCID 962 | — |
| Product | {4-Methoxy-3-[4-morpholin-4-yl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid | HCID 44187533 | — |
Reaction Steps
{4-Methoxy-3-[4-morpholin-4-yl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester (0.43 mmol) ini MeOH and H2O was treated with lithium hydroxide, and the reaction was stirred at 60° C. for 20 minutes. The mixture was acidified and concentrated, and the reside was purified by preparative HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08242145B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-30c719c05ffb4a22b7aa3dd3e4e3a7e1 |
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| Source note | uspto-grants-2012_08 |
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