(1S,2R)-(-)-1-Amino-2-indanol → HCID 58237454, compound

HRID 885401Notes

Reaction equation

HRID 885401 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH:19]=O)[CH:6]=1.[CH2:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C@H:24]([NH2:31])[C@@H:23]1[OH:32]>>[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19][NH:31][C@H:24]2[C:25]3[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:22][C@H:23]2[OH:32])[CH:6]=1

Participants

3

Reactant 2

HCID 9866743(1S,2R)-(-)-1-Amino-2-indanolHCID 58237467[3-(4-Bromo-2-formyl-phenoxy)-phenyl]-acetic acid methyl ester

Product 1

HCID 58237454HCID 58237454, compound

Procedure

Prepared according to the procedure described in Example 45, Step 3, using the following starting materials: [3-(4-bromo-2-formyl-phenoxy)-phenyl]-acetic acid methyl ester and (1S,2R)-(−)-cis-1-amino-2-indanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0c52b1646e8d4d1a92f3e8b69a1a5d75
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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