(1S,2R)-(-)-1-Amino-2-indanol → (3-{2-[((1S,2R)-2-Hydroxy-indan-1-ylamino)-methyl]-4-trifluoromethyl-phenoxy}-phenyl)-acetic acid methyl ester

HRID 885403Notes

Reaction equation

HRID 885403 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH:22]=O)[CH:6]=1.[CH2:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[C@H:27]([NH2:34])[C@@H:26]1[OH:35]>>[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:20])([F:19])[F:21])=[CH:14][C:13]=2[CH2:22][NH:34][C@H:27]2[C:28]3[C:33](=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:25][C@H:26]2[OH:35])[CH:6]=1

Participants

3

Reactant 2

HCID 9866743(1S,2R)-(-)-1-Amino-2-indanolHCID 58237636[3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

Product 1

HCID 58237608(3-{2-[((1S,2R)-2-Hydroxy-indan-1-ylamino)-methyl]-4-trifluoromethyl-phenoxy}-phenyl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 45, Step 3, using the following starting materials: [3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester and (1S,2R)-(−)-cis-1-amino-2-indanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3717e7ec8c734578a635dac302ace60b
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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