(S)-2-Amino-indan-1-ol → (3-{2-[((S)-1-Hydroxy-indan-2-ylamino)-methyl]-4-trifluoromethyl-phenoxy}-phenyl)-acetic acid methyl ester

HRID 885409Notes

Reaction equation

HRID 885409 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH:22]=O)[CH:6]=1.[NH2:25][CH:26]1[CH2:34][C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[C@@H:27]1[OH:35]>>[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:20])([F:19])[F:21])=[CH:14][C:13]=2[CH2:22][NH:25][CH:26]2[CH2:34][C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[C@@H:27]2[OH:35])[CH:6]=1

Participants

3

Reactant 2

HCID 53893097(S)-2-Amino-indan-1-olHCID 58237636[3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

Product 1

HCID 58237669(3-{2-[((S)-1-Hydroxy-indan-2-ylamino)-methyl]-4-trifluoromethyl-phenoxy}-phenyl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 45, Step 3, using the following starting materials: [3-(2-formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester and (S)-2-amino-indan-1-ol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-429c70c7ee6740b2b0455980bdd9258a
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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