Phosgene → {3-[2-(2-Oxo-4,8b-dihydro-3aH-indeno[2,1-d]oxazol-3-ylmethyl)-4-trifluoromethyl-phenoxy]-phenyl}-acetic acid methyl ester

HRID 885410Notes

Reaction equation

HRID 885410 reaction equation
[CH3:1][O:2][C:3](=[O:34])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH:24]2[CH2:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[C@@H:25]2[OH:33])[CH:6]=1.[C:35](Cl)(Cl)=[O:36]>>[CH3:1][O:2][C:3](=[O:34])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:19])[F:20])=[CH:14][C:13]=2[CH2:22][N:23]2[CH:24]3[CH2:32][C:31]4[C:26]([CH:25]3[O:33][C:35]2=[O:36])=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH:6]=1

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 58237669(3-{2-[((S)-1-Hydroxy-indan-2-ylamino)-methyl]-4-trifluoromethyl-phenoxy}-phenyl)-acetic acid methyl ester

Product 1

HCID 58237561{3-[2-(2-Oxo-4,8b-dihydro-3aH-indeno[2,1-d]oxazol-3-ylmethyl)-4-trifluoromethyl-phenoxy]-phenyl}-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 45, Step 4, using the following starting materials: (3-{2-[((S)-1-hydroxy-indan-2-ylamino)-methyl]-4-trifluoromethyl-phenoxy}-phenyl)-acetic acid methyl ester and phosgene (1.9M in toluene).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3bc3ad5f1863465f8d40e2502602dff5
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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