HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → {3-[4-Bromo-2-(2-oxo-pyrrolidin-1-ylmethyl)-phenoxy]-phenyl}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | {3-[4-Bromo-2-(2-oxo-pyrrolidin-1-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester | HCID 67105918 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | {3-[4-Bromo-2-(2-oxo-pyrrolidin-1-ylmethyl)-phenoxy]-phenyl}-acetic acid | HCID 58237567 | — |
Reaction Steps
{3-[4-Bromo-2-(2-oxo-pyrrolidin-1-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester (0.35 mmol) in 1,4-dioxane and H2O was treated with lithium hydroxide at 50° C. for 30 minutes. The crude material was purified by preparative HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242145B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-26777b8118eb4749b8a437afc96a2665 |
| Source note | uspto-grants-2012_08 |