HCID 69016614, compound → HCID 178437439, compound

HRID 885435Notes

Reaction equation

HRID 885435 reaction equation
F[C:2]1[C:7]2[N:8](CC3C=CC4NC5C=CC=CC=5CCC=4C=3)[C:9]([CH2:11][CH2:12]C)=[N:10][C:6]=2[C:5]([CH3:30])=[CH:4][CH:3]=1.FC1C2NC(CCC)=[N:37]C=2C(C)=CC=1>>[CH2:11]([C:9]1[NH:8][C:7]2=[N:37][C:3]([CH3:2])=[CH:4][C:5]([CH3:30])=[C:6]2[N:10]=1)[CH3:12]

Participants

3

Reactant 2

HCID 69016614HCID 69016614, compoundHCID 69017423HCID 69017423, compound

Product 1

HCID 178437439HCID 178437439, compound

Procedure

[step 1] 2-(7-Fluoro-4-methyl-2-propylbenzimidazol-1-yl)methyl-10,11-dihydro-5H-dibenzo[b,f]azepine (370 mg, 92%) was obtained in the same manner as in step 1 of Example 1, using 4-fluoro-7-methyl-2-propylbenzimidazole (478 mg, 1.10 mmol), obtained in Reference Example 4, instead of 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine.

Sources & evidence

ORD record
ord-7bda75203b634bb4b8d4be262aaeb61d
Source dataset
uspto-grants-2012_08
Patent number
US08242151B2

Reaction notes

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