Dibutyltin oxide → HCID 178437423, compound

Participants

Reaction Conditions

Reaction Steps

5-(1-Cyanoethyl)-2-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-10,11-dihydro-5H-dibenzo[b,f]azepine (520 mg, 1.19 mmol) obtained in step 1 of Example 19 was dissolved in toluene (12 mL), and the solution was added with trimethylsilylazide (2.54 mL, 19.1 mmol) and dibutyltinoxide (177 mg, 0.71 mmol), followed by stirring at 70° C. for 2 days. The mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform/methanol=25/1) to give the title compound (compound 22, 354 mg, 62%).

Provenance & Evidence