(E)-2-(2-hydroxymethyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propiononitrile → HCID 178437439, compound

HRID 885439Notes

Reaction equation

HRID 885439 reaction equation
[CH2:1]([C:3]1[N:13](CC2C=CC3/C(=C(\C)/C#N)/C4C=CC=CC=4CCC=3C=2)[C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2].OCC1C=CC2/C(=C(\C)/C#N)/C3C=CC=CC=3CCC=2C=1>>[CH2:1]([C:3]1[NH:13][C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 67210474(E)-2-(2-hydroxymethyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propiononitrileHCID 69016785(E)-2-[2-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene]propiononitrile

Product 1

HCID 178437439HCID 178437439, compoundYield 227.7%

Procedure

[step 1] (E)-2-[2-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene]propiononitrile (399 mg, 69%) was obtained in the same manner as in step 1 of Example 36, using (E)-2-(2-hydroxymethyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propiononitrile (367 mg, 1.3 mmol) obtained in Reference Example 6 and 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (366 mg, 2.1 mmol) instead of 5-chloro-2-ethyl-7-methyl-3H-imidazo[4,5-b]pyridine.

Sources & evidence

ORD record
ord-fb65a2b7c3044364908647319d7a4b9d
Source dataset
uspto-grants-2012_08
Patent number
US08242151B2

Reaction notes

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