Triphenylphosphine → HCID 69020207, compound

Participants

Reaction Steps

[step 1] (E)-(3-Hydroxymethyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene)acetonitrile (JP-B-2526005; 250 mg, 0.950 mmol) and 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (250 mg, 1.42 mmol) were dissolved in THF (9.5 mL), and the solution was added with polymer supported triphenylphosphine (633 mg, 1.90 mmol) and di-t-butyl azodicarboxylate (437 mg, 1.90 mmol) at 0° C., followed by stirring at room temperature for 3 hr. The mixture was filtrated and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to give (E)-[3-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene]acetonitrile (158 mg, 26%).

Provenance & Evidence