HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 885448Generated: October 25, 2026
[4-Fluoro-3-(trifluoromethyl)phenyl]methanamine → (4-fluoro-3-trifluoromethyl-benzyl)-(1-methyl-1H-benzimidazol-2-yl)-amine
https://huagongshe.com/reaction/885448
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | [4-Fluoro-3-(trifluoromethyl)phenyl]methanamine | HCID 522270 | — |
| Reactant | 2-chloro-1-methyl-1H-1,3-benzodiazole | HCID 663080 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (4-fluoro-3-trifluoromethyl-benzyl)-(1-methyl-1H-benzimidazol-2-yl)-amine | HCID 66890247 | — |
Reaction Steps
A mixture of 2-chloro-1-methyl-1H-benzimidazole (915 mg, 5.5 mmol) and 4-fluoro-3-trifluoromethyl-benzylamine (4.24 g, 22.0 mmol) was stirred at 130° C. overnight. The resulting mixture was diluted with EtOAc, washed with H2O, dried over Na2SO4, filtered, and concentrated in vacuo. The resulting residue was purified by recrystallization from hexane to yield (4-fluoro-3-trifluoromethyl-benzyl)-(1-methyl-1H-benzimidazol-2-yl)-amine MS 324 (M+1)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08242157B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-81ffa7b9b8b94474bf5adb220217ff77 |
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| Source note | uspto-grants-2012_08 |
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