Ethanamine, 2,2,2-trifluoro- → HCID 19784794, compound

HRID 885452Notes

Reaction equation

HRID 885452 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[F:11][C:12]([F:16])([F:15])[CH2:13][NH2:14]>CS(C)=O>[N+:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:14][CH2:13][C:12]([F:16])([F:15])[F:11])([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 738951-Fluoro-2-nitrobenzene

Product 1

HCID 19784794HCID 19784794, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 1-fluoro-2-nitro-benzene (1.55 g, 11.0 mmol), 2,2,2-trifluoro-ethylamine (3.27 g, 33.0 mmol) and DMSO (4.5 mL) was heated at 120° C. for 24 h. The resulting mixture was poured onto ice/H2O and the resultant precipitate was collected by filtration, washed with H2O, and hexanes to yield (2-nitro-phenyl)-(2,2,2-trifluoro-ethyl)-amine MS 221 (M+1)+

Workup

  1. additionThe resulting mixture was poured onto ice/H2O
  2. filtrationthe resultant precipitate was collected by filtration
  3. washwashed with H2O, and hexanes

Sources & evidence

ORD record
ord-4929692b89e8459aa2829acdb8174a08
Source dataset
uspto-grants-2012_08
Patent number
US08242157B2

Reaction notes

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